The atopic dance
File(s)Atopic dance 2017 CACI.pdf (380.3 KB)
Published version
Author(s)
Levin, Michael E
Warner, John O
Type
Journal Article
Abstract
The atopic march refers to the disorders that commonly occur together and track with age in a characteristic order, starting with atopic dermatitis often associated with food allergy, then inhalant allergy contributing to the development of asthma and then rhinitis. The implication of this model of the allergic march is that there is a linear progression from one manifestation to another, and a further assumption that there is a single predominant mechanism (of ‘atopy’ which may be defined as the susceptibility to becoming allergic) behind all the manifestations. New insights from the advent of molecular medicine indicate that many allergic diseases are better seen as syndromes comprising multiple phenotypes, with different gene/environment interactions and consequent endotypes. In addition, there are multiple contributing aetiologies to each ‘syndrome’ and complicated interactions between them are better visualised as causal networks, rather than as linear cause and effect. These factors and the variability of progression from one form of atopy to another are at odds with the concept of the ‘atopic march’. We, therefore, suggest that the ‘Atopic March’ is an outdated concept which might be better considered as an ‘Atopic Tango’.
Date Issued
2017-09-01
Date Acceptance
2017-06-01
Citation
Current Allergy and Clinical Immunology, 2017, 30 (3), pp.150-154
ISSN
1609-3607
Publisher
Allergy Society of South Africa
Start Page
150
End Page
154
Journal / Book Title
Current Allergy and Clinical Immunology
Volume
30
Issue
3
Copyright Statement
© Publisher: Allergy Society of South Africa (ALLSA) 2017
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000412709400004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Allergy
ASTHMA PHENOTYPES
ALLERGIC DISEASE
CLASSIFICATION
ENDOTYPES
Publication Status
Published