Olfactory dysfunction is worse in primary ciliary dyskinesia compared with other causes of chronic sinusitis in children
File(s)
Author(s)
Pifferi, Massimo
Bush, Andrew
Rizzo, Michele
Tonacci, Alessandro
Di Cicco, Maria
Type
Journal Article
Abstract
Cilia have multiple functions including olfaction. We hypothesised that olfactory function could be impaired in primary ciliary dyskinesia (PCD). Olfaction, nasal nitric oxide (nNO) and sinus CT were assessed in patients with PCD and non-PCD sinus disease, and healthy controls (no CT scan). PCD and non-PCD patients had similar severity of sinus disease. Despite this, defective olfaction was more common in patients with PCD (P<0.0001) and more severe in patients with PCD with major Transmission Electron Microscopy (TEM) abnormalities. Only in classical PCD did olfaction inversely correlate with sinusitis and nNO. We speculate that defective olfaction in PCD is primary in nature.
Date Issued
2018-10-01
Date Acceptance
2018-02-12
Citation
Thorax, 2018, 73, pp.980-982
URI
DOI
ISSN
1468-3296
Publisher
BMJ Publishing Group
Start Page
980
End Page
982
Journal / Book Title
Thorax
Volume
73
Copyright Statement
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/29490941
PII: thoraxjnl-2017-210661
Subjects
nasal nitric oxide
olfactory dysfunction
primary ciliary dyskinesia
sensory cilia
sinusitis
Publication Status
Published
Coverage Spatial
England