Virus infection impairs fungal response to stress: effect of salt
File(s)
Published version
Author(s)
Kotta-Loizou, Ioly
Type
Journal Article
Abstract
Infection with Aspergillus fumigatus polymycovirus 1 (AfuPmV-1) weakens the resistance of biofilms of common A. fumigatus reference strain Af293 in intermicrobial competition with Pseudomonas aeruginosa, and sensitizes A. fumigatus for antifungal effects of nikkomycin Z. We compared the sensitivity of two virus-infected (VI) and one virus-free (VF) Af293 strains to hypertonic salt. Salt stress impairs the growth of VI and VF at all times; VF control growth always exceeds VI, and VF growth in salt always exceeds VI. Since VF growth exceeds VI in the presence and absence of salt, we also examined growth in salt as a percentage of control growth. Initially, as a percentage of control, VI exceeded VF, but at 120 h VF began to exceed VI consistently even by this measure; thus, at that time the growth of VF in salt surges in relation to control growth, or, alternatively, its growth in salt persists compared to the relative inhibition of VI. In summary, virus infection impairs the response of A. fumigatus to several different stresses, including hypertonic salt.
Date Issued
2023-03-10
Date Acceptance
2023-03-09
Citation
Viruses, 2023, 15 (3), pp.1-8
ISSN
1999-4915
Publisher
MDPI AG
Start Page
1
End Page
8
Journal / Book Title
Viruses
Volume
15
Issue
3
Copyright Statement
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.mdpi.com/1999-4915/15/3/718
Publication Status
Published
Article Number
718
Date Publish Online
2023-03-10