Imaging and molecular mechanisms of Alzheimer's fisease: a review
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Alzheimer’s disease is the most common form of dementia and is a significant burden for affected patients, carers, and health systems. Great advances have been made in understanding its pathophysiology, to a point that we are moving from a purely clinical diagnosis to a biological one based on the use of biomarkers. Among those, imaging biomarkers are invaluable in Alzheimer’s, as they provide an in vivo window to the pathological processes occurring in Alzheimer’s brain. While some imaging techniques are still under evaluation in the research setting, some have reached widespread clinical use. In this review, we provide an overview of the most commonly used imaging biomarkers in Alzheimer’s disease, from molecular PET imaging to structural MRI, emphasising the concept that multimodal imaging would likely prove to be the optimal tool in the future of Alzheimer’s research and clinical practice.
Date Issued
2018-12-01
Date Acceptance
2018-11-14
Citation
International Journal of Molecular Sciences, 2018, 19 (12)
ISSN
1422-0067
Publisher
MDPI AG
Journal / Book Title
International Journal of Molecular Sciences
Volume
19
Issue
12
Copyright Statement
©2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000455323500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Multidisciplinary
Chemistry
Alzheimer's disease
positron emission tomography (PET)
magnetic resonance imaging (MRI)
POSITRON-EMISSION-TOMOGRAPHY
MILD COGNITIVE IMPAIRMENT
BLOOD-BRAIN-BARRIER
PITTSBURGH COMPOUND B
PERIPHERAL BENZODIAZEPINE-RECEPTOR
CEREBRAL GLUCOSE-METABOLISM
PARTIAL VOLUME CORRECTION
BETA-AMYLOID BURDEN
FLORBETAPIR F 18
IN-VIVO
Publication Status
Published
Article Number
ARTN 3702
Date Publish Online
2018-11-22