Decreased Time to Treatment Initiation for Multidrug-Resistant Tuberculosis Patients after Use of Xpert MTB/RIF Test, Latvia
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Few studies have examined whether the Xpert MTB/RIF test improves time to treatment initiation for persons with multidrug-resistant tuberculosis (MDR TB). We determined the impact of this test in Latvia, where it was introduced in 2010. After descriptive analyses of pulmonary MDR TB patients in Latvia during 2009–2012, time to treatment initiation was calculated, and univariate and multivariable accelerated failure time models were constructed. Univariate results showed strong evidence of an association between having rifampin-resistant TB detected by Xpert MTB/RIF and reduced time to treatment initiation versus the test not being used. A multivariable model stratifying by previous TB showed similar results. Our finding that in Latvia, time to treatment initiation was decreased for MDR TB cases that were rifampin-resistant TB by XpertMTB/RIF has implications for the use of this test in other settings with a high burden of MDR TB in which rifampin resistance is highly predictive of MDR TB.
Date Issued
2016-03-31
Date Acceptance
2016-03-01
Citation
Emerging Infectious Diseases, 2016, 22 (3), pp.482-490
ISSN
1080-6059
Publisher
Centers for Disease Control and Prevention
Start Page
482
End Page
490
Journal / Book Title
Emerging Infectious Diseases
Volume
22
Issue
3
Copyright Statement
All materials published in Emerging Infectious Diseases are in the public domain and can be used without permission. Stagg HR, White PJ, Riekstiņa V, Cīrule A, Šķenders G, Leimane V, et al. Decreased time to treatment initiation for multidrug-resistant tuberculosis patients after use of Xpert MTB/RIF test, Latvia. Emerg Infect Dis. 2016 Mar [date cited]. http://dx.doi.org/10.3201/eid2203.151227
Subjects
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
MODEL
Publication Status
Published