Designing genetic feedback controllers
File(s)
Accepted version
Author(s)
Harris, Andreas WK
Dolan, James A
Kelly, Ciaran L
Anderson, James
Papachristodoulou, Antonis
Type
Journal Article
Abstract
By incorporating feedback around systems we wish to manipulate, it is possible to improve their performance and robustness properties to meet pre-specified design objectives. For decades control engineers have been successfully implementing feedback controllers for complex mechanical and electrical systems such as aircraft and sports cars. Natural biological systems use feedback extensively for regulation and adaptation but apart from the most basic designs, there is no systematic framework for designing feedback controllers in Synthetic Biology. In this paper we describe how classical approaches from linear control theory can be used to close the loop. This includes the design of genetic circuits using feedback control and the presentation of a biological phase lag controller.
Date Issued
2015-09-14
Date Acceptance
2015-06-28
Citation
IEEE Transactions on Biomedical Circuits and Systems, 2015, 9 (4), pp.475-484
ISSN
1932-4545
Publisher
Institute of Electrical and Electronics Engineers
Start Page
475
End Page
484
Journal / Book Title
IEEE Transactions on Biomedical Circuits and Systems
Volume
9
Issue
4
Copyright Statement
© 2015 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000361970600003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Technology
Engineering, Biomedical
Engineering, Electrical & Electronic
Engineering
Feedback control
robust control
systems and synthetic biology
TOBACCO ETCH VIRUS
SYNTHETIC BIOLOGY
ESCHERICHIA-COLI
IN-VIVO
EXPRESSION
PROTEIN
TRANSCRIPTION
CONSTRUCTION
POLYPROTEIN
PROMOTER
Publication Status
Published