The expanding spectrum of antibody-mediated rejection: should we include cases where no anti-HLA donor-specific antibody is detected?
File(s)
Author(s)
Randhawa, Parmjeet
Roufosse, Candice
Type
Journal Article
Abstract
Antibody-mediated rejection (ABMR) in a renal transplant biopsy is most often diagnosed by a combination of microvascular injury (MVI), C4d deposition and presence of circulating DSA. MVI designates the leucocyte margination reaction in glomeruli (glomerulitis, Banff score g) and in peritubular capillaries (peritubular capillaritis, Banff score ptc). MVI (sum of Banff scores g+ptc) is a morphological feature rather than a diagnosis, and is not specific for ABMR.
Date Issued
2019-03-01
Date Acceptance
2018-09-05
Citation
American Journal of Transplantation, 2019, 19 (3), pp.622-624
ISSN
1600-6135
Publisher
Wiley
Start Page
622
End Page
624
Journal / Book Title
American Journal of Transplantation
Volume
19
Issue
3
Copyright Statement
© 2018 Wiley. This is the accepted version of the following article: Randhawa, P. and Roufosse, C. (2018), The Expanding Spectrum of Antibody‐Mediated Rejection: Should we Include Cases Where No Anti‐HLA Donor‐Specific Antibody is Detected?. Am J Transplant. Accepted Author Manuscript., which has been published in final form at https://dx.doi.org/10.1111/ajt.15114.
Sponsor
Roche Organ Transplant Research Foundation
Imperial College Healthcare NHS Trust- BRC Funding
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/30203616
Grant Number
n/a
RDA28
Subjects
Science & Technology
Life Sciences & Biomedicine
Surgery
Transplantation
alloantibody
alloantigen
classification systems: Banff classification
clinical research/practice
editorial/personal viewpoint
immunohistochemistry
kidney transplantation/nephrology
pathology/histopathology
rejection: antibody-mediated (ABMR)
PROSPECTS
alloantibody
alloantigen
classification systems: Banff classification
clinical research/practice
editorial/personal viewpoint
immunohistochemistry
kidney transplantation/nephrology
pathology/histopathology
rejection: antibody-mediated (ABMR)
Surgery
11 Medical and Health Sciences
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2018-09-11