Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Date Issued
2017-03-27
Date Acceptance
2017-03-03
Citation
NATURE GENETICS, 2017, 49 (5), pp.680-691
ISSN
1061-4036
Publisher
NATURE PUBLISHING GROUP
Start Page
680
End Page
691
Journal / Book Title
NATURE GENETICS
Volume
49
Issue
5
Copyright Statement
© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. The final publication is available at https://dx.doi.org/10.1038/ng.3826
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000400051400008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
CLEAR-CELL CARCINOMA
BREAST-CANCER
COMMON VARIANTS
TELOMERE LENGTH
RISK
ASSOCIATION
ENDOMETRIOSIS
METAANALYSIS
POPULATION
MUTATIONS
Developmental Biology
11 Medical And Health Sciences
06 Biological Sciences
Publication Status
Published