Rapid, non-invasive measurement of gastric emptying rate using transcutaneous fluorescence spectroscopy
File(s)boe-12-7-4249.pdf (6 MB)
Published version
Author(s)
Type
Journal Article
Abstract
Gastric emptying rate (GER) signifies the rate at which the stomach empties following ingestion of a meal and is relevant to a wide range of clinical conditions. GER also represents a rate limiting step in small intestinal absorption and so is widely assessed for research purposes. Despite the clinical and physiological importance of gastric emptying, methods used to measure GER possess a series of limitations (including being invasive, slow or unsuitable for certain patient populations). Here, we present a new technique based on transcutaneous (through-the-skin) fluorescence spectroscopy that is fast, non-invasive, and does not require the collection of samples or laboratory-based analysis. Thus, this approach has the potential to allow immediate reporting of clinical results. Using this new method, participants receive an oral dose of a fluorescent contrast agent and a wearable probe detects the uptake of the agent from the gut into the blood stream. Analysis of the resulting data then permits the calculation of GER. We compared our spectroscopic technique to the paracetamol absorption test (a clinically approved GER test) in a clinical study of 20 participants. Results demonstrated good agreement between the two approaches and, hence, the clear potential of transcutaneous fluorescence spectroscopy for clinical assessment of GER.
Date Issued
2021-07-01
Date Acceptance
2021-06-08
ISSN
2156-7085
Publisher
The Optical Society
Start Page
4249
End Page
4264
Journal / Book Title
Biomedical Optics Express
Volume
12
Issue
7
Copyright Statement
© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. The Author(s) agree that all copies of the Work made under any of the above rights shall prominently include the following copyright notice: “© 2021 Optical Society of America. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.”
Sponsor
National Institute of Health Research
Identifier
https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-7-4249&id=452609
Subjects
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Optics
Radiology, Nuclear Medicine & Medical Imaging
Biochemistry & Molecular Biology
PARACETAMOL ABSORPTION
FUNCTIONAL DYSPEPSIA
SOLIDS
GASTROPARESIS
DIAGNOSIS
PREDICTORS
LIQUIDS
0205 Optical Physics
0912 Materials Engineering
Publication Status
Published
Date Publish Online
2021-06-21