Hybrid reflection retrieval method for terahertz dielectric imaging of human bone
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Published version
OA Location
Author(s)
Freer, Suzanna
Sui, Cong
Hanham, Stephen M
Grover, Liam M
Navarro-Cia, Miguel
Type
Journal Article
Abstract
Terahertz imaging is becoming a biological imaging modality in its own right, alongside the more mature infrared and X-ray techniques. Nevertheless, extraction of hyperspectral, biometric information of samples is limited by experimental challenges. Terahertz time domain spectroscopy reflection measurements demand highly precise alignment and suffer from limitations of the sample thickness. In this work, a novel hybrid Kramers-Kronig and Fabry-Pérot based algorithm has been developed to overcome these challenges. While its application is demonstrated through dielectric retrieval of glass-backed human bone slices for prospective characterisation of metastatic defects or osteoporosis, the generality of the algorithm offers itself to wider application towards biological materials.
Date Issued
2021-08-01
Date Acceptance
2021-05-24
Citation
Biomedical Optics Express, 2021, 12 (8), pp.4807-4820
ISSN
2156-7085
Publisher
Optical Society of America
Start Page
4807
End Page
4820
Journal / Book Title
Biomedical Optics Express
Volume
12
Issue
8
Copyright Statement
© 2021 The Author(s). Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further
distribution of this work must maintain attribution to the author(s) and the published article’s title, journal
citation, and DOI.
distribution of this work must maintain attribution to the author(s) and the published article’s title, journal
citation, and DOI.
License URL
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000683035000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Optics
Radiology, Nuclear Medicine & Medical Imaging
Biochemistry & Molecular Biology
KRAMERS-KRONIG RELATIONS
RELIABLE METHOD
SUM-RULES
WATER
SPECTROSCOPY
PARAMETERS
EXTRACTION
Publication Status
Published
Date Publish Online
2021-07-12