Insulin and metabolic substrates during human sepsis
File(s)
Published version
Author(s)
Finney, SJ
Type
Journal Article
Abstract
Rusavy and colleagues recently endeavoured to dissect out the metabolic effects of insulin in patients
with severe sepsis, in the setting of normoglycaemia. Twenty stable patients were studied 3–7 days
after admission using a euglycaemic clamp at two supraphysiological insulin levels. Increased doses of
exogenous insulin caused preferential use of glucose as a metabolic substrate, while total energy
expenditure remained constant. Consequently, hyperinsulinaemia reduced tissue oxygen demand and
catabolism of protein in patients with sepsis; the benefits of these effects are not proven. The effects of
insulin at different time points in sepsis were not examined.
with severe sepsis, in the setting of normoglycaemia. Twenty stable patients were studied 3–7 days
after admission using a euglycaemic clamp at two supraphysiological insulin levels. Increased doses of
exogenous insulin caused preferential use of glucose as a metabolic substrate, while total energy
expenditure remained constant. Consequently, hyperinsulinaemia reduced tissue oxygen demand and
catabolism of protein in patients with sepsis; the benefits of these effects are not proven. The effects of
insulin at different time points in sepsis were not examined.
Date Issued
2004-08-01
Date Acceptance
2004-05-25
Citation
Critical Care, 2004, 8 (4), pp.227-228
ISSN
1364-8535
Publisher
BioMed Central
Start Page
227
End Page
228
Journal / Book Title
Critical Care
Volume
8
Issue
4
Copyright Statement
© 2004 BioMed Central Ltd. Licensed under the Creative Commons Attribution License 4.0.
Subjects
Science & Technology
Life Sciences & Biomedicine
Critical Care Medicine
General & Internal Medicine
CRITICAL CARE MEDICINE
glucose
insulin
metabolic response
severe sepsis
CRITICALLY-ILL PATIENTS
GLYCEMIC CONTROL
THERAPY
Publication Status
Published