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  5. Passive cavitation detection with a needle hydrophone array
 
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Passive cavitation detection with a needle hydrophone array
File(s)
1.pdf (1.73 MB)
Accepted version
Author(s)
Jiang, Zheng
Sujarittam, Krit
Yildiz, Betul Ilbilgi
Dickinson, Robert J
Choi, James J
Type
Journal Article
Abstract
Therapeutic ultrasound and microbubble technologies seek to drive systemically administered microbubbles into oscillations that safely manipulate tissue or release drugs. Such procedures often detect the unique acoustic emissions from microbubbles with the intention of using this feedback to control the microbubble activity. However, most sensor systems reported introduce distortions to the acoustic signal. Acoustic shockwaves, a key emission from microbubbles, are largely absent in reported recording, possibly due to the sensors being too large or too narrowband, or having strong phase distortions. Here, we built a sensor array that countered such limitations with small, broadband sensors and a low phase distorting material. We built 8 needle hydrophones with polyvinylidene fluoride (PVDF, diameter: 2 mm) then fit them into a 3D-printed scaffold in a two-layered, staggered arrangement. Using this array, we monitored microbubbles exposed to therapeutically-relevant ultrasound pulses (center frequency: 0.5 MHz, peak-rarefactional pressure: 130-597 kPa, pulse length: 4 cycles). Our tests revealed that the hydrophones were broadband with the best having a sensitivity of -224.8± 3.2 dB re 1 V/μPa from 1 to 15 MHz. The array was able to capture shockwaves generated by microbubbles. The signal-to-noise (SNR) ratio of the array was approximately 2 times higher than individual hydrophones. Also, the array could localize microbubbles (-3dB lateral resolution: 2.37 mm) and determine the cavitation threshold (between 161 kPa and 254 kPa). Thus, the array accurately monitored and localized microbubble activities, and may be an important technological step towards better feedback control methods and safer and more effective treatments.
Date Issued
2022-01
Date Acceptance
2021-10-08
Citation
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2022, 69 (1), pp.233-240
URI
http://hdl.handle.net/10044/1/92850
URL
https://ieeexplore.ieee.org/document/9570324/authors#authors
DOI
https://www.dx.doi.org/10.1109/tuffc.2021.3120263
ISSN
0885-3010
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Start Page
233
End Page
240
Journal / Book Title
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume
69
Issue
1
Copyright Statement
© 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Identifier
https://ieeexplore.ieee.org/document/9570324/authors#authors
Subjects
Science & Technology
Technology
Acoustics
Engineering, Electrical & Electronic
Engineering
Cavitation threshold
needle hydrophone array
passive cavitation detection
shockwave
BLOOD-BRAIN-BARRIER
FOCUSED ULTRASOUND
ACOUSTIC CAVITATION
COMPLEX DECONVOLUTION
FIBEROPTIC HYDROPHONE
LOCALIZATION
DISRUPTION
OUTPUT
Acoustics
Contrast Media
Microbubbles
Ultrasonic Therapy
Ultrasonography
Contrast Media
Ultrasonography
Ultrasonic Therapy
Microbubbles
Acoustics
02 Physical Sciences
09 Engineering
Acoustics
Publication Status
Published
Date Publish Online
2021-10-14
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