Advances in genetics: widening our understanding of prostate cancer
File(s)
Author(s)
Pine, AC
Fioretti, FF
Brooke, GN
Bevan, CL
Type
Journal Article
Abstract
Prostate cancer is a leading cause of cancer-related death in Western men. Our understanding of the genetic alterations associated with disease predisposition, development, progression, and therapy response is rapidly improving, at least in part, owing to the development of next-generation sequencing technologies. Large advances have been made in our understanding of the genetics of prostate cancer through the application of whole-exome sequencing, and this review summarises recent advances in this field and discusses how exome sequencing could be used clinically to promote personalised medicine for prostate cancer patients.
Date Issued
2016-06-27
Date Acceptance
2016-06-01
Citation
F1000 Research, 2016, 5
ISSN
2046-1402
Publisher
F1000Research
Journal / Book Title
F1000 Research
Volume
5
Copyright Statement
© 2016 Pine AC et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
License URL
Sponsor
Cancer Research UK
Prostate Cancer UK
Grant Number
C37990/A12196
S12-026
Subjects
Androgen
Cancer progression
DNA damage repair
Metastasis
Personalised Medicine
Prostate Cancer
Transcriptome
WES
Whole Exome Sequencing
Publication Status
Published
Article Number
1512