A link between frontal white matter integrity and dizziness in cerebral small vessel disease
Author(s)
Type
Journal Article
Abstract
One in three older people (>60 years) complain of dizziness which often remains unexplained despite specialist assessment. We investigated if dizziness was associated with vascular injury to white matter tracts relevant to balance or vestibular self-motion perception in sporadic cerebral small vessel disease (age-related microangiopathy). We prospectively recruited 38 vestibular clinic patients with idiopathic (unexplained) dizziness and 36 age-matched asymptomatic controls who underwent clinical, cognitive, balance, gait and vestibular assessments, and structural and diffusion brain MRI. Patients had more vascular risk factors, worse balance, worse executive cognitive function, and worse ankle vibration thresholds in association with greater white matter hyperintensity in frontal deep white matter, and lower fractional anisotropy in the genu of the corpus callosum and the right inferior longitudinal fasciculus. A large bihemispheric white matter network had less structural connectivity in patients. Reflex and perceptual vestibular function was similar in patients and controls. Our results suggest cerebral small vessel disease is involved in the genesis of dizziness through its effect on balance.
Date Issued
2022-06-23
Date Acceptance
2022-06-21
Citation
NeuroImage: Clinical, 2022, 35, pp.1-12
ISSN
2213-1582
Publisher
Elsevier
Start Page
1
End Page
12
Journal / Book Title
NeuroImage: Clinical
Volume
35
Copyright Statement
© 2022 Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Identifier
https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000828145400005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
Subjects
Science & Technology
Life Sciences & Biomedicine
Neuroimaging
Neurosciences & Neurology
Dizziness
Small vessel disease
Older
Balance
White matter
COGNITIVE IMPAIRMENT
ELDERLY-PATIENTS
BODY SWAY
BRAIN
THRESHOLDS
GAIT
CLASSIFICATION
DISEQUILIBRIUM
PERCEPTION
ACTIVATION
Publication Status
Published
Article Number
ARTN 103098
Date Publish Online
2022-06-23