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Altered GABAA α5 subunit expression in the hypothalamic paraventricular nucleus of hypertensive and pregnant rats
File(s)
Author(s)
Cork, SC
Chazot, PL
Pyner, S
Type
Journal Article
Abstract
A characteristic of both hypertension and pregnancy is increased sympathetic nerve activity. The level of sympathetic activation is determined, in part, by a tonic GABAergic inhibition arising from the hypothalamic paraventricular nucleus (PVN). In hypertension, decreases in GABAergic inhibition and increases in glutamatergic excitation within the PVN contribute to this sympatho-excitation. In late-term pregnancy however, the sympatho-excitation appears to be mediated by decreases in GABAergic inhibition only. This study examined whether changes in subunit expression for GABAA receptors in the PVN could provide a molecular basis for the sympatho-excitation characteristic of hypertension and pregnancy. Hypertension and pregnancy were accompanied by significant decrease in the GABAA receptor α5 subunit in the PVN. We suggest that decreases in the α5 subunit of the GABAA receptor may be important in mediating the sympatho-excitation observed in both hypertension and pregnancy.
Date Issued
2016-03-30
Date Acceptance
2016-03-19
Citation
Neuroscience Letters, 2016, 620, pp.148-153
URI
DOI
ISSN
1872-7972
Publisher
Elsevier
Start Page
148
End Page
153
Journal / Book Title
Neuroscience Letters
Volume
620
Copyright Statement
© 2016 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY
license (http://creativecommons.org/licenses/by/4.0/).
License URL
Subjects
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Hypertension
Late-term pregnant rats
GABA(A) receptor alpha 5 subunit expression
Sympatho-excitation
Paraventricular nucleus of the
hypothalamus
PRESYMPATHETIC NEURONS
PROGESTERONE METABOLITES
SYMPATHETIC ACTIVATION
TONIC INHIBITION
SPINAL-CORD
RECEPTORS
PLASTICITY
ORGANIZATION
HIPPOCAMPUS
INTEGRATION
GABA(A) receptor α5 subunit expression
Paraventricular nucleus of the hypothalamus
1109 Neurosciences
1702 Cognitive Science
1701 Psychology
Publication Status
Published