Overview of a collaborative global effort to address the burden of familial hypercholesterolaemia
File(s)
Published version
Author(s)
Lyons, Alexander RM
Stevens, Christophe AT
Dharmayat, Kanika I
Vallejo-Vaz, Dr Antonio J
Ray, Kausik K
Type
Journal Article
Abstract
This is an overview of the EAS Familial Hypercholesterolaemia (FH) Studies Collaboration (FHSC) global consortium and registry (established 2015), which broadly addresses the global burden of FH. Eighty-seven National Lead Investigators from 74 countries form this expanding global consortium, and this global registry currently includes pooled data on 70,000 participants from participating countries to facilitate FH surveillance. Published first results from this global registry concluded that FH is diagnosed late, and management of LDL-cholesterol falls below guideline recommendations, and therefore earlier detection of FH and wider use of combination therapy is required. Further FHSC studies will follow on updated data including new countries, participants and variables, and non-DNA genetic information, and on the remaining cohorts in the registry. FHSC cross-sectional collaborative global studies are expected to promote FH detection earlier in life to subsequently initiate early lipid lowering therapy to reduce lifelong exposure to cumulative LDL-cholesterol thus reducing cardiovascular disease risk.
Date Issued
2024-03
Date Acceptance
2023-11-13
Citation
Indian Heart Journal, 2024, 76 (Supplement 1), pp.S113-S116
ISSN
0019-4832
Publisher
Elsevier
Start Page
S113
End Page
S116
Journal / Book Title
Indian Heart Journal
Volume
76
Issue
Supplement 1
Copyright Statement
© 2023 Published by Elsevier, a division of RELX India, Pvt. Ltd on behalf of Cardiological Society of India. This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/37981086
Subjects
Atherosclerosis
Dyslipidaemias
Familial hypercholesterolaemia
FHSC
Hypercholesterolaemia
LDL-Cholesterol
Registry
Publication Status
Published
Coverage Spatial
India
Date Publish Online
2023-11-18