Intraductal magnetic resonance imaging of cholangiocarcinoma - a practical possibility
File(s)fonc-14-1306242.pdf (784.85 KB)
Published version
Author(s)
Syms, Richard RA
Wadsworth, Christopher A
Kardoulaki, Evgenia
Titapun, Attapol
Boonphongsathian, Wuttisak
Type
Journal Article
Abstract
Intraductal T2 mapping based on a catheter receiver is proposed as a method of visualizing the extent of intraductal and periductal cholangiocarcinoma (CCA). Compared to external receivers, internal receivers provide locally enhanced signal-to-noise ratios by virtue of their lower field-of-view for body noise, allowing smaller voxels and higher resolution. However, inherent radial sensitivity variation and segmentation for patient safety both distort image brightness. We discuss simulated T2 weighted images and T2 maps, and in vitro images obtained using a thin film catheter receiver of a freshly resected liver specimen containing a polypoid intraductal tumor from a patient with CCA. T2 mapping provides a simple method of compensating non-uniform signal reception patterns of catheter receivers, allowing the visualization of tumor extent without contrast enhancement and potentially quantitative tissue characterization. Potential advantages and disadvantages of in vivo intraductal imaging are considered.
Date Issued
2024-04-08
Date Acceptance
2024-03-26
Citation
Frontiers in Oncology, 2024, 14
ISSN
2234-943X
Publisher
Frontiers Media S.A.
Journal / Book Title
Frontiers in Oncology
Volume
14
Copyright Statement
Copyright © 2024 Syms, Wadsworth, Kardoulaki, Titapun, Boonphongsathien, Sa-Ngiamwibool, Zhang, Taylor-Robinson, Chamadol and Loilome. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
License URL
Identifier
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1306242/full
Publication Status
Published
Article Number
1306242
Date Publish Online
2024-04-08