Primary prevention of food allergy: translating evidence from clinical trials to population-based recommendations
File(s)
Published version
Author(s)
Turner, PJ
Campbell, Dianne E
Boyle, R
Levin, Michael E
Type
Journal Article
Abstract
Given the prevalence and impact of childhood food allergy, there is increasing interest in interventions targeting disease prevention. Although interventions such as early introduction of dietary peanut have demonstrated efficacy in a small number of well-conducted randomized clinical trials, evidence for broader effectiveness and successful implementation at a population level is still lacking, although epidemiological data suggest that such strategies are likely to be successful, at least for peanut. In this commentary, we explore the issues of translating evidence of efficacy studies (performed under optimal conditions) to make policy recommendations at a population level, and highlight potential benefits, harms, and unintended consequences of making population-based recommendations on the basis of randomized controlled trials. We discuss the complexity and barriers to effective primary and secondary prevention intervention implementation in resource-poor settings.
Date Issued
2018-03-07
Date Acceptance
2017-12-15
Citation
Journal of Allergy and Clinical Immunology: In Practice, 2018, 6 (2), pp.367-375
ISSN
2213-2198
Publisher
Elsevier
Start Page
367
End Page
375
Journal / Book Title
Journal of Allergy and Clinical Immunology: In Practice
Volume
6
Issue
2
Copyright Statement
© 2017 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Sponsor
Medical Research Council (MRC)
National Institute for Health Research
Grant Number
MR/K010468/1
RDD02
Subjects
Allergy
Implementation
Peanut
Prevention
Translation
Publication Status
Published