Quantitative analysis of cell nucleus organisation
File(s)Quantitative analysis of cell nucleus organisation.pdf (216.51 KB)
Published version
Author(s)
Shiels, C
Adams, NM
Islam, SA
Stephens, DA
Freemont, PS
Type
Journal Article
Abstract
There are almost 1,300 entries for higher eukaryotes in the Nuclear Protein Database. The proteins' subcellular distribution patterns within interphase nuclei can be complex, ranging from diffuse to punctate or microspeckled, yet they all work together in a coordinated and controlled manner within the three-dimensional confines of the nuclear volume. In this review we describe recent advances in the use of quantitative methods to understand nuclear spatial organisation and discuss some of the practical applications resulting from this work.
Date Issued
2007-07-27
Date Acceptance
2007-07-01
Citation
Plos Computational Biology, 2007, 3 (7), pp.1161-1168
ISSN
1553-7358
Publisher
Public Library of Science
Start Page
1161
End Page
1168
Journal / Book Title
Plos Computational Biology
Volume
3
Issue
7
Copyright Statement
© 2007 Shiels et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Grant Number
BB/H013423/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemical Research Methods
Mathematical & Computational Biology
Biochemistry & Molecular Biology
RNA-polymerase-II
Scale chromatin organization
Human-chromosome territories
Interphase nuclei
Spatial-distribution
Transcription sites
Human-lymphocytes
Messenger-RNA
PML bodies
Inactive genes
Cell Nucleus
Models, Biological
Nuclear Proteins
Bioinformatics
Biological Sciences
Information And Computing Sciences
Mathematical Sciences
Publication Status
Published