Review and meta-analysis of the evidence for choosing between specific pyrethroids for programmatic purposes
Author(s)
Type
Journal Article
Abstract
Pyrethroid resistance is widespread in malaria vectors. However, differential mortality in discriminating dose assays to different pyrethroids is often observed in wild populations. When this occurs, it is unclear if this differential mortality should be interpreted as an indication of differential levels of susceptibility within the pyrethroid class, and if so, if countries should consider selecting one specific pyrethroid for programmatic use over another. A review of evidence from molecular studies, resistance testing with laboratory colonies and wild populations, and mosquito behavioural assays were conducted to answer these questions. Evidence suggested that in areas where pyrethroid resistance exists, different results in insecticide susceptibility assays with specific pyrethroids currently in common use (deltamethrin, permethrin, α-cypermethrin, and λ-cyhalothrin) are not necessarily indicative of an operationally relevant difference in potential performance. Consequently, it is not advisable to use rotation between these pyrethroids as an insecticide-resistance management strategy. Less commonly used pyrethroids (bifenthrin and etofenprox) may have sufficiently different modes of action, though further work is needed to examine how this may apply to insecticide resistance management
Date Issued
2021-09-14
Date Acceptance
2021-09-11
Citation
Insects, 2021, 12 (9)
ISSN
2075-4450
Publisher
MDPI AG
Journal / Book Title
Insects
Volume
12
Issue
9
Copyright Statement
Copyright: © 2021 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/)
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/)
License URL
Sponsor
The Global Fund to Fight AIDS Tuberculosis and Maleria
Medical Research Council (MRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000699818800001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
Collab_TA5_RBPS04426_ICL
MR/R015600/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Entomology
pyrethroid
pyrethroid resistance
insecticide resistance
insecticide resistance management
vector control
malaria
malaria control
mosquito
Anopheles
INSECTICIDE RESISTANCE
GENE-EXPRESSION
Publication Status
Published
Article Number
ARTN 826