Next generation strategy for tuning the thermoresponsive properties of micellar and hydrogel drug delivery vehicles using ionic liquids
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Amongst the greatest challenges in developing injectable controlled thermoresponsive micellar and hydrogel drug delivery vehicles include tuning the cloud point (CP) and reducing the gelation temperature (Tgel), below 37 °C, without compromising stability and solubility. Here, a unique strategy is employed using ionic liquid (IL) matrices to produce stable micellar and hydrogel delivery vehicles of distinct thermoresponsive properties. Each formulation includes the in-house synthesised polymer OEGMA30020-b-BuMA22-b-DEGMA11 with FITC-IgG. Both micellar-IL and hydrogel-IL formulations exhibit enhanced stability following 120 days of storage under 4 °C compared to in phosphate buffered saline (PBS). Visual tests demonstrate that the CP of the micellar-IL carriers can be finely tuned (31- 46 °C). Rheology measurements show that hydrogel strength is significantly increased and Tgel is reduced, from 40 °C in PBS to 30 °C with IL. Finally, a unique stabilisation mechanism is proposed, triggered by the synergetic action of the excipients and IL in each system
Date Issued
2022-04-28
Date Acceptance
2022-03-16
Citation
Polymer Chemistry, 2022, 13 (16), pp.2340-2350
ISSN
1759-9954
Publisher
Royal Society of Chemistry (RSC)
Start Page
2340
End Page
2350
Journal / Book Title
Polymer Chemistry
Volume
13
Issue
16
Copyright Statement
© The Royal Society of Chemistry 2022. This article is licensed under aCreative Commons Attribution 3.0 Unported Licence (https://creativecommons.org/licenses/by/3.0/)
License URL
Sponsor
Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (E
Engineering & Physical Science Research Council (EPSRC)
Identifier
https://pubs.rsc.org/en/Content/ArticleLanding/2022/PY/D2PY00053A
Grant Number
EP/R511547/1
MMRE_P75852
EP/R013764/1
Subjects
Science & Technology
Physical Sciences
Polymer Science
BLOCK-COPOLYMER MICELLES
PROTEIN
RELEASE
TEMPERATURE
STABILITY
TRANSITION
SYNERESIS
GELATION
ENHANCE
POLYOLS
0303 Macromolecular and Materials Chemistry
0307 Theoretical and Computational Chemistry
Publication Status
Published
Date Publish Online
2022-03-25