Development of allergic sensitization and its relevance to paediatric asthma
File(s)Table 1.docx (18.85 KB)
Accepted version
Author(s)
Custovic, A
Oksel, C
Type
Journal Article
Abstract
Purpose of review: The purpose of this review is to summarize the recent evidence on the distinct atopic phenotypes and their relationship with childhood asthma. We start by considering definitions and phenotypic classification of atopy and then review evidence on its association with asthma in children. Recent findings: It is now well recognised that both asthma and atopy are complex entities encompassing various different sub-groups that also differ in the way they interconnect. The lack of gold standards for diagnostic markers of atopy and asthma further adds to the existing complexity over diagnostic accuracy and definitions. Although recent statistical phenotyping studies contributed significantly to our understanding of these heterogeneous disorders, translating these findings into meaningful information and effective therapies requires further work on understanding underpinning biological mechanisms. Summary: The disaggregation of allergic sensitization may help predict how the allergic disease is likely to progress. One of the important questions is how best to incorporate tests for the assessment of allergic sensitisation into diagnostic algorithms for asthma, both in terms of confirming asthma diagnosis, and the assessment of future risk.
Date Issued
2018-04-01
Date Acceptance
2018-01-24
ISSN
1473-6322
Publisher
Lippincott, Williams & Wilkins
Start Page
109
End Page
116
Journal / Book Title
Current Opinion in Allergy and Clinical Immunology
Volume
18
Issue
2
Copyright Statement
© 2018 Wolters Kluwer Health, Inc. All rights reserved.
Sponsor
Medical Research Council (MRC)
Wellcome Trust
Grant Number
MR/K002449/1
108818/Z/15/Z and 108818/Z/15/
Subjects
1107 Immunology
Allergy
Publication Status
Published