Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition
File(s)
Accepted version
Author(s)
Obón-Santacana, Mireia
Luján-Barroso, Leila
Freisling, Heinz
Naudin, Sabine
Boutron-Ruault, Marie-Christine
Type
Journal Article
Abstract
Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
Date Issued
2020-01-01
Date Acceptance
2019-04-16
Citation
International Journal of Cancer, 2020, 146 (1), pp.76-84
ISSN
0020-7136
Publisher
Wiley
Start Page
76
End Page
84
Journal / Book Title
International Journal of Cancer
Volume
146
Issue
1
Copyright Statement
© 2019 UICC. This is the accepted version of the following article: Obón‐Santacana, M. , Luján‐Barroso, L. , Freisling, H. , Naudin, S. , Boutron‐Ruault, M. , Mancini, F. R., Rebours, V. , Kühn, T. , Katzke, V. , Boeing, H. , Tjønneland, A. , Olsen, A. , Overvad, K. , Lasheras, C. , Rodríguez‐Barranco, M. , Amiano, P. , Santiuste, C. , Ardanaz, E. , Khaw, K. , Wareham, N. J., Schmidt, J. A., Aune, D. , Trichopoulou, A. , Thriskos, P. , Peppa, E. , Masala, G. , Grioni, S. , Tumino, R. , Panico, S. , Bueno‐de‐Mesquita, B. , Sciannameo, V. , Vermeulen, R. , Sonestedt, E. , Sund, M. , Weiderpass, E. , Skeie, G. , González, C. A., Riboli, E. and Duell, E. J. (2020), Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition. Int. J. Cancer, 146: 76-84, which has been published in final form at https://doi.org/10.1002/ijc.32415 .
Sponsor
Commission of the European Communities
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31107546
Grant Number
SP23-CT-2005-006438
Subjects
EPIC
diet
intake
nuts
pancreatic cancer
prospective cohort study
seeds
Publication Status
Published online
Coverage Spatial
United States
Date Publish Online
2019-06-06