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The effect of preservation temperature on liver, kidney and pancreas tissue ATP in animal and preclinical human models
File(s)
Author(s)
Bellini, Maria Irene
Yiu, Janice
Nozdrin, Mikhail
Papalois, Vassilios
Type
Journal Article
Abstract
The recent advances in machine perfusion (MP) technology involve settings ranging between hypothermic, subnormothermic and normothermic temperatures. Tissue level ATP is a long-established marker of viability and functionality and is universal for all organs. In the midst of a growing number of complex clinical parameters for the quality assessment of graft prior to transplantation, a revisit of ATP may shed light on the underlying reconditioning mechanisms of different perfusion temperatures in the form of restoration of metabolic and energy status. This article aims to review and critically analyse animal and preclinical human studies (discarded grafts) during MP of three abdominal organs (liver, kidney and pancreas) in which ATP was a primary end-point. A selective review of recent novel reconditioning approaches relevant to mitigation of graft ischaemia-reperfusion injury via MP and for different perfusion temperatures was also conducted. With a current reiterated interest for oxygenation during MP, a re-introduction of tissue ATP levels may be valuable for graft viability assessment prior to transplantation. Further studies may help delineate the benefits of selective perfusion temperatures on organs viability.
Date Issued
2019-09-09
Date Acceptance
2019-09-02
Citation
Journal of Clinical Medicine, 8 (9)
URI
DOI
ISSN
2077-0383
Publisher
MDPI AG
Journal / Book Title
Journal of Clinical Medicine
Volume
8
Issue
9
Copyright Statement
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Subjects
cell metabolism
ischaemia reperfusion injury
machine perfusion
organ reconditioning
transplantation
1103 Clinical Sciences
Publication Status
Published online
Article Number
1421
Date Publish Online
2019-09-09