Intruders or protectors – the multifaceted role of B cells in CNS disorders
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
B lymphocytes are immune cells studied predominantly in the context of peripheral humoral immune responses against pathogens. Evidence has been accumulating in recent years on the diversity of immunomodulatory functions that B cells undertake, with particular relevance for pathologies of the central nervous system (CNS). This review summarizes current knowledge on B cell populations, localization, infiltration mechanisms, and function in the CNS and associated tissues. Acute and chronic neurodegenerative pathologies are examined in order to explore the complex, and sometimes conflicting, effects that B cells can have in each context, with implications for disease progression and treatment outcomes. Additional factors such as aging modulate the proportions and function of B cell subpopulations over time and are also discussed in the context of neuroinflammatory response and disease susceptibility. A better understanding of the multifactorial role of B cell populations in the CNS may ultimately lead to innovative therapeutic strategies for a variety of neurological conditions.
Date Issued
2024-01-10
Date Acceptance
2023-12-20
Citation
Frontiers in Cellular Neuroscience, 2024, 17
ISSN
1662-5102
Publisher
Frontiers Media S.A.
Journal / Book Title
Frontiers in Cellular Neuroscience
Volume
17
Copyright Statement
©2024 Aspden, Murphy, Kashlan, Xiong, Poznansky and Sîrbulescu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms
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Publication Status
Published
Article Number
1329823
Date Publish Online
2024-01-10