The role of complement in IgA nephropathy
File(s)
Accepted version
Author(s)
Tortajada, Agustin
Gutierrez, Eduardo
Pickering, Matthew C
Praga Terente, Manuel
Medjeral-Thomas, Nicholas
Type
Journal Article
Abstract
IgA nephropathy (IgAN) is common and often progresses to end stage renal disease. IgAN encompasses a wide range of histology and clinical features. IgAN pathogenesis is incompletely understood; the current multi-hit hypothesis of IgAN pathogenesis does not explain the range of glomerular inflammation and renal injury associated with mesangial IgA deposition. Although associations between IgAN and glomerular and circulating markers of complement activation are established, the mechanism of complement activation and contribution to glomerular inflammation and injury are not defined. Recent identification of specific complement pathways and proteins in severe IgAN cases had advanced our understanding of complement in IgAN pathogenesis. In particular, a growing body of evidence implicates the complement factor H related proteins 1 and 5 and lectin pathway as pathogenic in a subset of patients with severe disease. These data suggest complement deregulation and activity may be dominant drivers of renal injury in IgAN. Thereby, markers of complement activation may identify IgAN patients likely to progress to significant renal impairment and complement inhibition may emerge as an effective method of preventing and reducing glomerular injury in IgAN.
Date Issued
2019-10-01
Date Acceptance
2019-07-16
Citation
Molecular Immunology, 2019, 114, pp.123-132
ISSN
0161-5890
Publisher
Elsevier
Start Page
123
End Page
132
Journal / Book Title
Molecular Immunology
Volume
114
Copyright Statement
© 2019 Published by Elsevier Ltd. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Wellcome Trust
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31351413
PII: S0161-5890(19)30435-3
Grant Number
212252/Z/18/Z
Subjects
Complement
Glomerulonephritis
IgA nephropathy
Publication Status
Published
Coverage Spatial
England
Date Publish Online
2019-07-24