Differential expression of E-cadherin and catenins in ovarian sex cord stromal tumours
File(s)
Author(s)
Type
Journal Article
Abstract
Aims Sex cord stromal tumours (SCSTs) of the ovary encompass several histological tumour subtypes that are defined by characteristic histological features. Some can show morphological overlap with other subtypes of SCSTs, as well as with non-SCSTs. The E-cadherin/catenin complex constitutes the adherens junction, which is well developed in epithelial tissue, but the constituent molecules are also expressed in several non-epithelial tumours. The aim of this study was to determine whether the expression patterns of E-cadherin and catenins in ovarian SCSTs can be of diagnostic utility. Methods and results We studied the expression of E-cadherin, α-, β- and γ-catenin in 55 tumours using immunohistochemistry. We found that all tumour subtypes showed nuclear expression of E-cadherin, while only microcystic stromal tumours (MCSTs) displayed a distinct profile, with nuclear localization of all three catenins in almost all cases. Conclusions We conclude that the E-cadherin expression profile in SCSTs can assist in distinguishing between SCSTs and non-SCSTs in which there is no nuclear expression of E-cadherin. The nuclear localization of catenins may be of potential use in distinguishing MCST from other subtypes of SCST.
Date Issued
2016-07-11
Date Acceptance
2016-01-22
ISSN
0309-0167
Publisher
Wiley
Start Page
298
End Page
306
Journal / Book Title
Histopathology
Volume
69
Issue
2
Copyright Statement
This is the peer reviewed version of the following article: Stavrinou S, Clark A, Irving J, Lee C-H, Oliva E, Young R, Sriraksa R, Magdy N, Van Noorden S, McCluggage W G & El-Bahrawy M (2016) Histopathology 69, 298–306, which has been published in final form at https://dx.doi.org/10.1111/his.12937. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Subjects
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Pathology
catenin
E-cadherin
ovary
sex cord
stromal
tumour
GRANULOSA-CELL TUMOR
BETA-CATENIN
NUCLEAR-LOCALIZATION
ALPHA-CATENIN
HUMAN CANCER
ADHESION
MUTATION
SUPPRESSOR
MOLECULES
COMPLEX
Biomarkers, Tumor
Cadherins
Desmoplakins
Female
Humans
Immunohistochemistry
Middle Aged
Ovarian Neoplasms
Ovary
Sex Cord-Gonadal Stromal Tumors
alpha Catenin
beta Catenin
1103 Clinical Sciences
Publication Status
Published