Implant materials and prosthetic joint infection: the battle with the biofilm
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Published version
Author(s)
Davidson, Donald James
Spratt, David
Liddle, Alexander David
Type
Journal Article
Abstract
• Prosthetic joint infection (PJI) is associated with poor clinical outcomes and is expensive to treat.
• Although uncommon overall (affecting between 0.5% and 2.2% of cases), PJI is one of the most commonly encountered complications of joint replacement and its incidence is increasing, putting a significant burden on healthcare systems.
• Once established, PJI is extremely difficult to eradicate as bacteria exist in biofilms which protect them from antibiotics and the host immune response.
• Improved understanding of the microbial pathology in PJI has generated potential new treatment strategies for prevention and eradication of biofilm associated infection including modification of implant surfaces to prevent adhesion of bacteria.
• Much research is currently ongoing looking at different implant surface coatings and modifications, and although most of this work has not translated into clinical medicine there has been some early clinical success.
• Although uncommon overall (affecting between 0.5% and 2.2% of cases), PJI is one of the most commonly encountered complications of joint replacement and its incidence is increasing, putting a significant burden on healthcare systems.
• Once established, PJI is extremely difficult to eradicate as bacteria exist in biofilms which protect them from antibiotics and the host immune response.
• Improved understanding of the microbial pathology in PJI has generated potential new treatment strategies for prevention and eradication of biofilm associated infection including modification of implant surfaces to prevent adhesion of bacteria.
• Much research is currently ongoing looking at different implant surface coatings and modifications, and although most of this work has not translated into clinical medicine there has been some early clinical success.
Date Issued
2019-11-05
Date Acceptance
2019-04-01
Citation
EFORT Open Reviews, 2019, 4 (11)
ISSN
2058-5241
Publisher
British Editorial Society of Bone and Joint Surgery
Journal / Book Title
EFORT Open Reviews
Volume
4
Issue
11
Copyright Statement
© 2019 The author(s). This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0) licence (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed.
Sponsor
Orthopaedic Research UK
Royal College of Surgeons of England
Grant Number
Orthopaedic Research UK
Royal College of Surgeons of England
Publication Status
Published
Date Publish Online
2019-11-05