Prenatal, early-life and childhood exposure to air pollution and lung function: the ALSPAC cohort
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
RATIONALE: Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health. OBJECTIVES: To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy and childhood in a UK population-based birth cohort. METHODS: Individual exposures to source-specific particulate matter with diameter ≤10µm (PM10) during each trimester, 0-6 months, 7-12 months (1990-1993) and up to age 15 years (1991-2008) were examined in relation to %predicted Forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) at ages 8(N=5,276) and 15(N=3,446) years, usinglinear regression models adjusted for potential confounders. A profile regression model was used to identify sensitive time periods. MEASUREMENTS AND MAIN RESULTS: We did not find clear evidence for a sensitive exposure period for PM10 from road-traffic: at age 8 years, 1µg/m3 higher exposure during the first trimester was associated with lower %predicted of FEV1(-0.826, 95%CI:-1.357 to -0.296) and FVC(-0.817, 95%CI:-1.357 to -0.276), but similar associations were seen for exposures for other trimesters, 0-6 months, 7-12 months, and 0-7 years. Associations were stronger among boys, children whose mother had a lower education level or smoked during pregnancy. For PM10 from all sources, the third trimester was associated with lower %predicted of FVC (-1.312, 95%CI: -2.100 to -0.525). At age 15 years, no adverse associations were seen with lung function. CONCLUSIONS: Exposure to road-traffic PM10 during pregnancy may result in small but significant reductions in lung function at age 8 years.
Date Issued
2020-07-01
Date Acceptance
2020-03-04
Citation
American Journal of Respiratory and Critical Care Medicine, 2020, 202 (1), pp.112-123
ISSN
1073-449X
Publisher
American Thoracic Society
Start Page
112
End Page
123
Journal / Book Title
American Journal of Respiratory and Critical Care Medicine
Volume
202
Issue
1
Copyright Statement
© 2020 by the American Thoracic Society
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/32142356
Subjects
ALSPAC
Air pollution
children
lung function
traffic
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2020-03-06