Defend or reproduce? Muscle-derived glutamate determines an immune/reproductive energetic tradeoff
File(s)karpac previewIMAAM8.pdf (374.89 KB)
Accepted version
Author(s)
Mineo, Alessandro
Miguel-Aliaga, Irene
Type
Journal Article
Abstract
There are dramatic disparities in infection susceptibility within populations. In this issue of Cell Metabolism, Zhao and Karpac uncover a muscle-adipose-gut axis in Drosophila that explains variability in pathogen susceptibility. The degree of intramuscular NF-kB activation accounts for differences in circulating glutamate, which enhances resistance at the expense of reproduction.
Date Issued
2021-12-07
Date Acceptance
2021-11-12
Citation
Cell Metabolism, 2021, 33 (12), pp.2307-2309
ISSN
1550-4131
Publisher
Cell Press
Start Page
2307
End Page
2309
Journal / Book Title
Cell Metabolism
Volume
33
Issue
12
Copyright Statement
© 2021 Elsevier Inc. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor
Commission of the European Communities
Grant Number
787470
Subjects
0601 Biochemistry and Cell Biology
1101 Medical Biochemistry and Metabolomics
Endocrinology & Metabolism
Publication Status
Published
Date Publish Online
2021-12-07