Perspective on oncogenic processes at the end of the beginning of cancer genomics

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OA Location

https://www.cell.com/cell/fulltext/S0092-8674(18)30313-1?_returnURL=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867418303131%3Fshowall%3Dtrue

Author(s)

Ding, Li

Bailey, Matthew H

Porta-Pardo, Eduard

Thorsson, Vesteinn

Colaprico, Antonio

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Type

Journal Article

Abstract

The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.

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Date Issued

2018-04-05

Date Acceptance

2018-03-13

Citation

Cell, 2018, 173 (2), pp.305-320.e10

URI

http://hdl.handle.net/10044/1/71217

DOI

https://www.dx.doi.org/10.1016/j.cell.2018.03.033

ISSN

0092-8674

Publisher

Elsevier

Start Page

305

End Page

320.e10

Journal / Book Title

Cell

Volume

173

Issue

2

Copyright Statement

© 2018 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Sponsor

SAIC-F-Frederick, Inc

Leidos Biomedical Research, Inc.

Identifier

http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429320200008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202

Grant Number

TCGA Pilot Program

15Y011ST

Subjects

Science & Technology

Life Sciences & Biomedicine

Biochemistry & Molecular Biology

Cell Biology

SOMATIC POINT MUTATIONS

DISCOVERY

CLASSIFICATION

EXPRESSION

BREAST

TUMORS

LANDSCAPE

DRIVER

IDENTIFICATION

INFORMATION

Publication Status

Published

Date Publish Online

2018-04-05