Wireless Capsule Endoscope for Targeted Drug Delivery: Mechanics and Design Considerations
File(s)
Accepted version
Author(s)
Woods, SP
Constandinou, TG
Type
Journal Article
Abstract
This paper describes a platform to achieve targeted drug delivery in next generation wireless capsule endoscopy. The platform consists of two highly novel sub-systems: one is a micro-positioning mechanism which can deliver 1ml of targeted medication and the other is a holding mechanism which gives the functionality of resisting peristalsis. The micro-positioning mechanism allows a needle to be positioned within a 22.5⁰ segment of a cylindrical capsule and be extendible by up to 1.5mm outside the capsule body. The mechanism achieves both these functions using only a single micro-motor and occupying a total volume of just 200mm³. The holding mechanism can be deployed diametrically opposite the needle in 1.8s and occupies a volume of just 270mm³. An in-depth analysis of the mechanics is presented and an overview of the requirements necessary to realise a total system integration is discussed. It is envisaged that the targeted drug delivery platform will empower a new breed of capsule micro-robots for therapy in addition to diagnostics for pathologies such as ulcerative colitis and small intestinal Crohn's disease.
Date Issued
2013-04
Citation
IEEE Transactions on Biomedical Engineering, 2013, 60 (4), pp.945-953
ISSN
0018-9294
Publisher
IEEE
Start Page
945
End Page
953
Journal / Book Title
IEEE Transactions on Biomedical Engineering
Volume
60
Issue
4
Copyright Statement
© 2012 IEEE.Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Description
11/0413 meb. Accepted version OK to pub.
Identifier
http://hdl.handle.net/10044/1/10976
Publication Status
Published