Modulation of diffusion rate of therapeutic peptide drugs using graphene oxide membranes
File(s)1512.08506v1.pdf (765.08 KB)
Accepted version
Author(s)
Puvirajesinghe, TM
Zhi, ZL
Craster, RV
Guenneau, S
Type
Working Paper
Abstract
We investigate diffusion of a peptide drug through Graphene Oxide (GO) membranes that are modeled as a porous layered laminate constructed from aligned flakes of GO. Our experiments using a peptide drug show a tunable non-linear dependence of the peptide concentration upon time. This is confirmed using numerical simulations with a diffusion equation accounting for the photothermal degradation of fluorophores and an effective percolation model. This modeling yields an interpretation of the control and delay of drug diffusion through GO membranes. The ability to modulate the density of hydrogel-like GO membranes to control drug release rates could be a step forwards in tailoring drug release properties of the hydrogels for therapeutic applications.
Date Issued
2015-12-21
Citation
2015
Copyright Statement
© The Author(s) 2015
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Identifier
http://arxiv.org/abs/1512.08506v1
Grant Number
EP/L024926/1
Subjects
cond-mat.mtrl-sci
physics.bio-ph