Methods from the theory of stochastic processes are increasingly being used to extend classical thermodynamics to mesoscopic non-equilibrium systems. One characteristic feature of these systems is that averaging the stochastic entropy with respect to an ensemble of stochastic trajectories leads to a second law of thermodynamics that quantifies the degree of departure from thermodynamic equilibrium. A well known mechanism for maintaining a diffusing particle out of thermodynamic equilibrium is stochastic resetting. In its simplest form, the position of the particle instantaneously resets to a fixed position x0 at a sequence of times generated from a Poisson process of constant rate r. Within the context of stochastic thermodynamics, instantaneous resetting to a single point is a unidirectional process that has no time-reversed equivalent. Hence, the average rate of entropy production calculated using the Gibbs–Shannon entropy cannot be related to the degree of time-reversal symmetry breaking. The problem of unidirectionality can be avoided by considering resetting to a random position or diffusion in an intermittent confining potential. In this paper we show how stochastic entropy production along sample paths of diffusion processes with resetting can be analyzed in terms of extensions of Itô's formula for stochastic differential equations (SDEs) that include both continuous and discrete processes. First, we use the stochastic calculus of jump-diffusion processes to calculate the rate of stochastic entropy production for instantaneous resetting, and show how previous results are recovered upon averaging over sample trajectories. Second, we formulate single-particle diffusion in a switching potential as a hybrid SDE and develop a hybrid extension of Itô's stochastic calculus to derive a general expression for the rate of stochastic entropy production. We illustrate the theory by considering overdamped Brownian motion in an intermittent harmonic potential. Finally, we calculate the average rate of entropy production for a population of non-interacting Brownian particles moving in a common switching potential. In particular, we show that the latter induces statistical correlations between the particles, which means that the total entropy is not given by the sum of the 1-particle entropies.