Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Multifunctional nanoparticles have been widely investigated for biomedical applications, such as
imaging, therapy, and drug delivery. Especially, photoactive nanoparticles have received great
attention as theranostic agents because of their heat-generating abilities after exposure to laser
irradiation. However, photostability and safety issues have been the technical hurdles for further
clinical applications. Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have
strong absorption in the near-infrared region, high photostability, and excellent biodegradability.
Optimized N-CNDs can be utilized not only as a new photoacoustic (PA) imaging agent but also as
a superior photothermal therapy (PTT) agent in vivo because of their strong optical absorption at
a specific wavelength. We used N-CNDs to perform in vivo/ex vivo noninvasive PA imaging of
sentinel lymph nodes via local delivery and performed PTT for cancer ablation therapy. Finally,
biodegradation and renal clearance were confirmed by performing whole-body PA monitoring and
a degradation test.
imaging, therapy, and drug delivery. Especially, photoactive nanoparticles have received great
attention as theranostic agents because of their heat-generating abilities after exposure to laser
irradiation. However, photostability and safety issues have been the technical hurdles for further
clinical applications. Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have
strong absorption in the near-infrared region, high photostability, and excellent biodegradability.
Optimized N-CNDs can be utilized not only as a new photoacoustic (PA) imaging agent but also as
a superior photothermal therapy (PTT) agent in vivo because of their strong optical absorption at
a specific wavelength. We used N-CNDs to perform in vivo/ex vivo noninvasive PA imaging of
sentinel lymph nodes via local delivery and performed PTT for cancer ablation therapy. Finally,
biodegradation and renal clearance were confirmed by performing whole-body PA monitoring and
a degradation test.
Date Issued
2016-09-22
Date Acceptance
2016-08-20
Citation
Theranostics, 2016, 6 (12), pp.2196-2208
ISSN
1838-7640
Publisher
Ivyspring International Publisher
Start Page
2196
End Page
2208
Journal / Book Title
Theranostics
Volume
6
Issue
12
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Publication Status
Published