Polymeric syntactic foams (PSF) are a kind of composite material, which consists of a polymer matrix reinforced by hollow thin wall glass micro-spheres. Because of their low density, low moisture absorption, relatively high specific strength and stiffness, PSF are often employed in aerospace and submarine applications in which they are subjected to a wide range of temperature conditions. Due to the temperature sensitivity of the polymer matrix, the physical and mechanical behaviour of PSFs is highly sensitive to temperature variations. Besides, their dynamic response is significantly affected by the strain rate. This research investigates the temperature and strain rate dependence of the mechanical behaviour of polyurethane, epoxy and nylon syntactic foams under compressive and tensile loads. The selected materials have in common that their mechanical characteristics, thermal properties, and dimensional stability make them suitable for both impact engineering and thermoforming applications. The experimental results, acquired over a temperature range from −25 °C to 100 °C at low and high strain rates, reveal a clear interplay between temperature and strain rate effects on the mechanical behaviour of the materials under investigation. This synergy is observed to vary based on both the matrix material and the loading mode. Notably, the rate dependency of polyurethane and nylon syntactic foams is significantly influenced by the testing temperature during compression, while in tension the influence of the temperature on the rate dependency is moderate or negligible. In contrast, the rate dependency of the epoxy syntactic foam remains largely unaffected by the testing temperature. Deformation and failure mechanisms were analysed by examining the failure surface of the tested samples using SEM micrographs.