EEG measures of sensorimotor processing and their development are abnormal in children with isolated dystonia and dystonic cerebral palsy
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
Dystonia is a disorder of sensorimotor integration associated with abnormal oscillatory activity within the basal ganglia-thalamo-cortical networks. Event-related changes in spectral EEG activity reflect cortical processing but are sparsely investigated in relation to sensorimotor processing in dystonia. This study investigates modulation of sensorimotor cortex EEG activity in response to a proprioceptive stimulus in children with dystonia and dystonic cerebral palsy (CP).
Proprioceptive stimuli, comprising brief stretches of the wrist flexors, were delivered via a robotic wrist interface to 30 young people with dystonia (20 isolated genetic/idiopathic and 10 dystonic CP) and 22 controls (mean age 12.7 years). Scalp EEG was recorded using the 10–20 international system and the relative change in post-stimulus power with respect to baseline was calculated for the alpha (8–12 Hz) and beta (14–30 Hz) frequency bands.
A clear developmental profile in event-related spectral changes was seen in controls. Controls showed a prominent early alpha/mu band event-related desynchronisation (ERD) followed by an event-related synchronisation (ERS) over the contralateral sensorimotor cortex following movement of either hand. The alpha ERD was significantly smaller in the dystonia groups for both dominant and non-dominant hand movement (ANCOVA across the 3 groups with age as covariate: dominant hand F(2,47) = 4.45 p = 0.017; non-dominant hand F(2,42) = 9.397 p < 0.001. Alpha ERS was significantly smaller in dystonia for the dominant hand (ANCOVA F(2,47) = 7.786 p = 0.001). There was no significant difference in ERD or ERS between genetic/idiopathic dystonia and dystonic CP.
Conclusion
Modulation of alpha/mu activity by a proprioceptive stimulus is reduced in dystonia, demonstrating a developmental abnormality of sensorimotor processing which is common to isolated genetic/idiopathic and acquired dystonia/dystonic CP.
Proprioceptive stimuli, comprising brief stretches of the wrist flexors, were delivered via a robotic wrist interface to 30 young people with dystonia (20 isolated genetic/idiopathic and 10 dystonic CP) and 22 controls (mean age 12.7 years). Scalp EEG was recorded using the 10–20 international system and the relative change in post-stimulus power with respect to baseline was calculated for the alpha (8–12 Hz) and beta (14–30 Hz) frequency bands.
A clear developmental profile in event-related spectral changes was seen in controls. Controls showed a prominent early alpha/mu band event-related desynchronisation (ERD) followed by an event-related synchronisation (ERS) over the contralateral sensorimotor cortex following movement of either hand. The alpha ERD was significantly smaller in the dystonia groups for both dominant and non-dominant hand movement (ANCOVA across the 3 groups with age as covariate: dominant hand F(2,47) = 4.45 p = 0.017; non-dominant hand F(2,42) = 9.397 p < 0.001. Alpha ERS was significantly smaller in dystonia for the dominant hand (ANCOVA F(2,47) = 7.786 p = 0.001). There was no significant difference in ERD or ERS between genetic/idiopathic dystonia and dystonic CP.
Conclusion
Modulation of alpha/mu activity by a proprioceptive stimulus is reduced in dystonia, demonstrating a developmental abnormality of sensorimotor processing which is common to isolated genetic/idiopathic and acquired dystonia/dystonic CP.
Date Issued
2021-01-19
Date Acceptance
2021-01-13
Citation
NeuroImage: Clinical, 2021, 30
ISSN
2213-1582
Publisher
Elsevier
Journal / Book Title
NeuroImage: Clinical
Volume
30
Copyright Statement
© 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33583764
PII: S2213-1582(21)00013-9
Subjects
COHERENCE
CONNECTIVITY
CORTEX
CORTICAL OSCILLATIONS
DEEP BRAIN-STIMULATION
DESYNCHRONIZATION
Dystonia
Dystonic cerebral palsy
Event-related desynchronisation
Event-related synchronisation
EVOKED-POTENTIALS
Life Sciences & Biomedicine
MOVEMENT
Mu modulation
MU RHYTHM
Neuroimaging
Neurosciences & Neurology
Science & Technology
Sensorimotor integration
SYNCHRONIZATION
Publication Status
Published
Coverage Spatial
Netherlands
Article Number
102569
Date Publish Online
2021-01-19