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  5. Predicting quality of overnight glycaemic control in type 1 diabetes using binary classifiers
 
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Predicting quality of overnight glycaemic control in type 1 diabetes using binary classifiers
File(s)
Manuscript_Guemes_et_al_IEEE-2019_JBHI-00521-2019.R2.pdf (1.17 MB)
Accepted version
Author(s)
Guemes, Amparo
Cappon, Giacomo
Hernandez, Bernard
Reddy, Monika
Oliver, Nick
more
Type
Journal Article
Abstract
In type 1 diabetes management, maintaining nocturnal blood glucose within target range can be challenging. Although semi-automatic systems to modulate insulin pump delivery, such as low-glucose insulin suspension and the artificial pancreas, are starting to become a reality, their elevated cost and performance below user expectations is hindering their adoption. Hence, a decision support system that helps people with type 1 diabetes, on multiple daily injections or insulin pump therapy, to avoid undesirable overnight blood glucose fluctuations (hyper- or hypoglycaemic) is an attractive alternative. In this paper, we introduce a novel data-driven approach to predict the quality of overnight glycaemic control in people with type 1 diabetes by analyzing commonly gathered data during the day-time period (continuous glucose monitoring data, meal intake and insulin boluses). The proposed approach is able to predict whether overnight blood glucose concentrations are going to remain within or outside the target range, and therefore allows the user to take the appropriate preventive action (snack or change in basal insulin). For this purpose, a number of popular established machine learning algorithms for classification were evaluated and compared on a publicly available clinical dataset (i.e. OhioT1DM). Although there is no clearly superior classification algorithm, this study indicates that, by using commonly gathered data in type 1 diabetes management, it is possible to predict the quality of overnight glycaemic control with reasonable accuracy (AUC-ROC= 0.7).
Date Issued
2020-05
Date Acceptance
2019-08-24
Citation
IEEE Journal of Biomedical and Health Informatics, 2020, 24 (5), pp.1439-1446
URI
http://hdl.handle.net/10044/1/73798
URL
https://ieeexplore.ieee.org/document/8836640
DOI
https://www.dx.doi.org/10.1109/JBHI.2019.2938305
ISSN
2168-2194
Publisher
Institute of Electrical and Electronics Engineers
Start Page
1439
End Page
1446
Journal / Book Title
IEEE Journal of Biomedical and Health Informatics
Volume
24
Issue
5
Copyright Statement
© 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Sponsor
Engineering & Physical Science Research Council (EPSRC)
Commission of the European Communities
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/31536025
Grant Number
EP/P00993X/1
689810
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2019-09-13
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