Myeloid cells in chronic liver inflammation
File(s)
Published version
Author(s)
Patseas, Dimitrios
El-Masry, Ahmed
Liu, Zuobin
Ramachandran, Prakash
Triantafyllou, Evangelos
Type
Journal Article
Abstract
Chronic liver disease represents a significant global health burden. Regardless of etiology, its pathogenesis is driven by persistent liver inflammation, which can lead to fibrosis, cirrhosis, and an increased risk of cancer development. Myeloid cells, including neutrophils, eosinophils, monocytes, macrophages, and dendritic cells, play diverse and critical roles in hepatic immunity and the maintenance of tissue homeostasis but are also involved in liver injury, disease progression, and resolution. With the emergence of high-resolution omics technologies and in vivo fate-mapping models, our understanding of myeloid cell ontogeny and functional heterogeneity has been significantly refined. In this review, we discuss current insights into the myeloid cell landscape in nonviral chronic liver inflammatory conditions and summarize the roles of myeloid cell subsets in disease pathogenesis.
Date Issued
2025-10-01
Date Acceptance
2025-06-27
Citation
Cellular and Molecular Immunology, 2025, 22, pp.1237-1261
ISSN
1672-7681
Publisher
Springer Nature
Start Page
1237
End Page
1261
Journal / Book Title
Cellular and Molecular Immunology
Volume
22
Issue
10
Copyright Statement
© The Author(s) 2025 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
License URL
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/40721870
PII: 10.1038/s41423-025-01324-4
Subjects
ALCOHOLIC HEPATITIS
Dendritic cells
DENDRITIC CELLS
HEPATIC STELLATE CELLS
HEPATOCELLULAR-CARCINOMA
Immunology
KUPFFER CELLS
Life Sciences & Biomedicine
Liver cancer
Liver fibrosis
Liver inflammation
Macrophages
NEUTROPHIL EXTRACELLULAR TRAPS
Neutrophils
NONALCOHOLIC STEATOHEPATITIS
PRIMARY BILIARY-CIRRHOSIS
PRIMARY SCLEROSING CHOLANGITIS
Science & Technology
SUPPRESSOR-CELLS
Publication Status
Published
Coverage Spatial
China
Date Publish Online
2025-07-28