Global Associations between UVR Exposure and Current Eczema Prevalence in Children from ISAAC Phase Three
File(s)
Accepted version
Accepted version
Author(s)
Fuertes, Elaine
Flohr, Carsten
Silverberg, Jonathan I
Standl, Marie
Strachan, David P
Type
Journal Article
Abstract
We sought to examine the relationship globally between UVR dose exposure and current eczema prevalences. ISAAC Phase Three provided data on eczema prevalence for 13- to 14-year-olds in 214 centers in 87 countries and for 6- to 7-year-olds in 132 centers in 57 countries. Linear and nonlinear associations between (natural log transformed) eczema prevalence and the mean, maximum, minimum, standard deviation, and range of monthly UV dose exposures were assessed using linear mixed-effects regression models. For the 13- to 14-year-olds, the country-level eczema prevalence was positively and linearly associated with country-level monthly mean (prevalence ratio = 1.31 [95% confidence interval = 1.05–1.63] per kJ/m2) and minimum (1.25 [1.06–1.47] per kJ/m2) UVR dose exposure. Linear and nonlinear associations were also observed for other metrics of UV. Results were similar in trend, but nonsignificant, for the fewer centers with 6- to 7-year-olds (e.g., 1.24 [0.96–1.59] per kJ/m2 for country-level monthly mean UVR). No consistent within-country associations were observed (e.g., 1.05 [0.89–1.23] and 0.92 [0.71–1.18] per kJ/m2 for center-level monthly mean UVR for the 13- to 14- and 6- to 7-year-olds, respectively). These ecological results support a role for UVR exposure in explaining some of the variation in global childhood eczema prevalence.
Date Issued
2017-06-01
Date Acceptance
2017-02-12
Citation
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2017, 137 (6), pp.1248-1256
ISSN
0022-202X
Publisher
ELSEVIER SCIENCE INC
Start Page
1248
End Page
1256
Journal / Book Title
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume
137
Issue
6
Copyright Statement
© 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401616900015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Dermatology
ATOPIC ECZEMA
CHILDHOOD ISAAC
CLIMATE
ASTHMA
ALLERGIES
MECHANISMS
MUTATIONS
POLLUTION
SYMPTOMS
RHINITIS
Publication Status
Published
Date Publish Online
2017-02-28