Obesity, ethnicity and risk of critical care, mechanical ventilation and mortality in patients admitted to hospital with COVID-19: Analysis of the ISARIC CCP-UK cohort.
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
OBJECTIVE: To investigate the association of obesity with in-hospital COVID-19 outcomes in different ethnic groups. METHODS: Patients admitted to hospital with COVID-19 in the United Kingdom through the Clinical Characterisation Protocol UK (CCP-UK) developed by the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) were included from 6th February to 12th October 2020. Ethnicity was classified as: white, South Asian, black and other minority ethnic groups. Outcomes were admission to critical care, mechanical ventilation and in-hospital mortality, adjusted for age, sex and chronic diseases. RESULTS: 54,254 (age = 76 years; 45.0% women) white, 3,728 (57 years; 41.1%) South Asian, 2,523 (58 years; 44.9%) black and 5,427 (61 years; 40.8%) other ethnicities were included. Obesity was associated with all outcomes in all ethnic groups, with associations strongest for black ethnicities. When stratified by ethnicity and obesity status, the OR for admission to critical care, mechanical ventilation and mortality in black ethnicities with obesity were 3.91 (3.13, 4.88), 5.03 (3.94, 6.63), 1.93 (1.49, 2.51) respectively, compared to white ethnicities without obesity. CONCLUSIONS: Obesity was associated with an elevated risk of in-hospital COVID-19 outcomes in all ethnic groups, with associations strongest in black ethnicities.
Date Issued
2021-03-23
Date Acceptance
2021-03-17
Citation
Obesity (Silver Spring, Md.), 2021, 29 (7), pp.1223-1230
ISSN
1071-7323
Publisher
Wiley
Start Page
1223
End Page
1230
Journal / Book Title
Obesity (Silver Spring, Md.)
Volume
29
Issue
7
Copyright Statement
© 2021 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society (TOS).
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the
original work is properly cited.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the
original work is properly cited.
License URL
Sponsor
National Institute for Health Research
National Institute for Health Research
Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
GlaxoSmithKline Biologicals
National Institute for Health Research
UKRI MRC COVID-19 Rapid Response Call
UK Research and Innovation
Identifier
https://www.ncbi.nlm.nih.gov/pubmed/33755331
Grant Number
NF-SI-0513-10150
HPRU-2012-10064
MR/R005982/1
MR/R005982/1
PO 4050681719
PO 3001965656
NIHR201385
MC_PC19025
1257927
Subjects
COVID-19
ISARIC
ethnic differences
ethnicity
obesity
Publication Status
Published
Coverage Spatial
United States
Date Publish Online
2021-03-23