Scalable high-affinity stabilization of magnetic iron oxide nanostructures by a biocompatible antifouling homopolymer
File(s)
Accepted version
Supporting information
Author(s)
Type
Journal Article
Abstract
Iron oxide nanostructures have been widely developed for biomedical applications, due to their magnetic properties and biocompatibility. In clinical application, the stabilization of these nanostructures against aggregation and non-specific interactions is typically achieved using weakly anchored polysaccharides, with better-defined and more strongly anchored synthetic polymers not commercially adopted due to complexity of synthesis and use. Here, we show for the first time stabilization and biocompatibilization of iron oxide nanoparticles by a synthetic homopolymer with strong surface anchoring and a history of clinical use in other applications, poly(2-methacryloyloxyethy phosphorylcholine) (poly(MPC)). For the commercially important case of spherical particles, binding of poly(MPC) to iron oxide surfaces and highly effective individualization of magnetite nanoparticles (20 nm) are demonstrated. Next-generation high-aspect ratio nanowires (both magnetite/maghemite and core-shell iron/iron oxide) are furthermore stabilized by poly(MPC)-coating, with nanowire cytotoxicity at large concentrations significantly reduced. The synthesis approach is exploited to incorporate functionality into the poly(MPC) chain is demonstrated by random copolymerization with an alkyne-containing monomer for click-chemistry. Taking these results together, poly(MPC) homopolymers and random copolymers offer a significant improvement over current iron oxide nanoformulations, combining straightforward synthesis, strong surface-anchoring and well-defined molecular weight.
Date Issued
2017-10-12
Date Acceptance
2017-10-12
Citation
ACS Applied Materials and Interfaces, 2017, 9 (46), pp.40059-40069
ISSN
1944-8244
Publisher
American Chemical Society
Start Page
40059
End Page
40069
Journal / Book Title
ACS Applied Materials and Interfaces
Volume
9
Issue
46
Copyright Statement
Copyright © 2017 American Chemical Society
Sponsor
Kaust
Grant Number
N/A
Subjects
biocompatible nanoparticles
iron oxide
maghemite
magnetic nanoparticles
magnetite
poly(MPC)
surface functionalization
surface-adsorbed polymers
0904 Chemical Engineering
0303 Macromolecular And Materials Chemistry
0306 Physical Chemistry (Incl. Structural)
Nanoscience & Nanotechnology
Publication Status
Published