Ex vivo tracking of endogenous CO with a ruthenium(II) complex
File(s)jacs.7b11158.pdf (1.76 MB)
Published version
Author(s)
Type
Journal Article
Abstract
A two-photon fluorescent probe based on a ruthenium(II) vinyl complex is capable of selectively detecting carbon monoxide in cells and ex vivo using mice with a subcutaneous air pouch as a model for inflammation. This probe combines highly selective and sensitive ex vivo detection of endogenous CO in a realistic model with facile, inexpensive synthesis, and displays many advantages over the widely used palladium-based systems.
Date Issued
2017-12-27
Date Acceptance
2017-11-28
Citation
Journal of the American Chemical Society, 2017, 139 (51), pp.18484-18487
ISSN
1520-5126
Publisher
American Chemical Society
Start Page
18484
End Page
18487
Journal / Book Title
Journal of the American Chemical Society
Volume
139
Issue
51
Copyright Statement
This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
License URL
Sponsor
The Leverhulme Trust
Identifier
https://pubs.acs.org/doi/10.1021/jacs.7b11158
Grant Number
RPG-2012-634
Subjects
Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
Chemistry
CARBON-MONOXIDE
LIVING CELLS
FLUORESCENT-PROBE
SELECTIVE DETECTION
FLUOROGENIC PROBES
HEME OXYGENASE-1
CARBONYLATION
AIR
General Chemistry
03 Chemical Sciences
Publication Status
Published
Date Publish Online
2017-11-28