Genomic epidemiology of penicillin-non-susceptible Streptococcus pneumoniae
File(s)
Author(s)
Dewe, Tamsin CM
D'Aetht, Joshua C
Croucher, Nicholas J
Type
Journal Article
Abstract
Penicillin-non-susceptible Streptococcus pneumoniae (PNSP) were first detected in the 1960s, and are now common worldwide, predominantly through the international spread of a limited number of strains. Extant PNSP are characterized by mosaic pbp2x, pbp2b and pbp1a genes generated by interspecies recombinations, with the extent of these alterations determining the range and concentrations of β-lactams to which the genotype is non-susceptible. The complexity of the genetics underlying these phenotypes has been the subject of both molecular microbiology and genome-wide association and epistasis analyses. Such studies can aid our understanding of PNSP evolution and help improve the already highly-performing bioinformatic methods capable of identifying PNSP from genomic surveillance data.
Date Issued
2019-10-01
Date Acceptance
2019-09-19
Citation
Microbial Genomics, 2019, 5 (10), pp.1-8
ISSN
2057-5858
Publisher
Microbiology Society
Start Page
1
End Page
8
Journal / Book Title
Microbial Genomics
Volume
5
Issue
10
Copyright Statement
© 2019 The Authors
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the
original work is properly cited.
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the
original work is properly cited.
Sponsor
Medical Research Council (MRC)
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000493924700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Grant Number
MR/R015600/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Genetics & Heredity
Microbiology
antibiotic resistance
pneumococcus
genomic epidemiology
penicillin
BINDING PROTEIN GENES
ANTIBIOTIC USE
BETA-LACTAM
RISK-FACTORS
CONJUGATE VACCINE
RESISTANT PNEUMOCOCCI
HORIZONTAL TRANSFER
UNITED-STATES
CARRIAGE
EVOLUTION
Publication Status
Published
Article Number
ARTN 000305
Date Publish Online
2019-10-14