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  5. Intrinsic neural excitability biases allocation and overlap of memory engrams
 
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Intrinsic neural excitability biases allocation and overlap of memory engrams
File(s)
Intrinsic Neural Excitability Biases Allocation and Overlap of Memory Engrams.pdf (893.47 KB)
Published version
Author(s)
Delamare, Geoffroy
Tome, Douglas Feitosa
Clopath, Claudia
Type
Journal Article
Abstract
Memories are thought to be stored in neural ensembles known as engrams that are specifically reactivated during memory recall. Recent studies have found that memory engrams of two events that happened close in time tend to overlap in the hippocampus and the amygdala, and these overlaps have been shown to support memory linking. It has been hypothesized that engram overlaps arise from the mechanisms that regulate memory allocation itself, involving neural excitability, but the exact process remains unclear. Indeed, most theoretical studies focus on synaptic plasticity and little is known about the role of intrinsic plasticity, which could be mediated by neural excitability and serve as a complementary mechanism for forming memory engrams. Here, we developed a rate-based recurrent neural network that includes both synaptic plasticity and neural excitability. We obtained structural and functional overlap of memory engrams for contexts that are presented close in time, consistent with experimental and computational studies. We then investigated the role of excitability in memory allocation at the network level and unveiled competitive mechanisms driven by inhibition. This work suggests mechanisms underlying the role of intrinsic excitability in memory allocation and linking, and yields predictions regarding the formation and the overlap of memory engrams.
Date Issued
2024-05-22
Date Acceptance
2024-03-25
Citation
The Journal of Neuroscience, 2024, 44 (21)
URI
http://hdl.handle.net/10044/1/113482
URL
https://www.jneurosci.org/content/44/21/e0846232024
DOI
https://www.dx.doi.org/10.1523/JNEUROSCI.0846-23.2024
ISSN
1529-2401
Publisher
Society for Neuroscience
Journal / Book Title
The Journal of Neuroscience
Volume
44
Issue
21
Copyright Statement
Copyright © 2024 Delamare et al.
This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
License URL
https://creativecommons.org/licenses/by/4.0/
Identifier
https://www.jneurosci.org/content/44/21/e0846232024
Subjects
COMPETITION
engram
excitability
Life Sciences & Biomedicine
LINKING
memory
memory allocation
memory linking
MODEL
NEURONS
Neurosciences
Neurosciences & Neurology
plasticity
Science & Technology
TIME
TRANSIENT
Publication Status
Published
Article Number
0846232024
Date Publish Online
2024-04-01
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