Mechanotransduction, the ability of cells to detect and react to
mechanical forces, is increasingly playing a critical role in a
variety of physiological and pathophysiological processes.
While the focus has previously been on the MAPK, NF-8B and
ROS generating pathways, ancient embryological pathways
have reached little attention. Recently, a surge of new studies
have been published on these pathways and their role in
mechanotransduction and this review paper aims to provide a
concise overview on the latest studies and brings them in to a
larger perspective. Special emphasis is on the non-canonical
aspects of the Wnt, TGF-b and Notch pathways and their role
in flow.