Dear Spiral user, We’re pleased to introduce Helix, https://helix.imperial.ac.uk/ Imperial’s new repository for research datasets. Please use Helix for all future dataset deposits. There is no change to Spiral - continue depositing as usual. For queries, contact the Research Data Management team at rdm-enquiries@imperial.ac.uk. Kind regards, the Spiral Team. The Spiral team
Synthetic biology tools to engineer microbial communities for biotechnology
File(s)
OA Location
Author(s)
McCarty, Nicholas S
Ledesma-Amaro, Rodrigo
Type
Journal Article
Abstract
Microbial consortia have been used in biotechnology processes, including fermentation, waste treatment, and agriculture, for millennia. Today, synthetic biologists are increasingly engineering microbial consortia for diverse applications, including the bioproduction of medicines, biofuels, and biomaterials from inexpensive carbon sources. An improved understanding of natural microbial ecosystems, and the development of new tools to construct synthetic consortia and program their behaviors, will vastly expand the functions that can be performed by communities of interacting microorganisms. Here, we review recent advancements in synthetic biology tools and approaches to engineer synthetic microbial consortia, discuss ongoing and emerging efforts to apply consortia for various biotechnological applications, and suggest future applications.
Date Issued
2019-02-01
Date Acceptance
2018-11-01
Citation
Trends in Biotechnology, 2019, 37 (2), pp.181-197
URI
DOI
ISSN
0167-7799
Publisher
Elsevier BV
Start Page
181
End Page
197
Journal / Book Title
Trends in Biotechnology
Volume
37
Issue
2
Copyright Statement
© 2018 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International licence. (CC BY 4.0 - https://creativecommons.org/licenses/by/4.0/)
Sponsor
Biotechnology and Biological Sciences Research Council (BBSRC)
Grant Number
BB/R01602X/1
Subjects
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
ESCHERICHIA-COLI
SACCHAROMYCES-CEREVISIAE
GENE-EXPRESSION
CONSORTIA
COMMUNICATION
ECOLOGY
SYSTEMS
ECOSYSTEMS
PRINCIPLES
EVOLUTION
biomaterials
bioproduction
microbial consortia
synthetic biology
synthetic consortia
synthetic microbial communities
06 Biological Sciences
09 Engineering
10 Technology
Biotechnology
Publication Status
Published
Date Publish Online
2018-11-26