From the exposome to mechanistic understanding of chemical-induced adverse effects.
File(s)
Published version
Author(s)
Type
Journal Article
Abstract
The exposome encompasses an individual's exposure to exogenous chemicals, as well as endogenous chemicals that are produced or altered in response to external stressors. While the exposome concept has been established for human health, its principles can be extended to include broader ecological issues. The assessment of exposure is tightly interlinked with hazard assessment. Here, we explore if mechanistic understanding of the causal links between exposure and adverse effects on human health and the environment can be improved by integrating the exposome approach with the adverse outcome pathway (AOP) concept that structures and organizes the sequence of biological events from an initial molecular interaction of a chemical with a biological target to an adverse outcome. Complementing exposome research with the AOP concept may facilitate a mechanistic understanding of stress-induced adverse effects, examine the relative contributions from various components of the exposome, determine the primary risk drivers in complex mixtures, and promote an integrative assessment of chemical risks for both human and environmental health.
Date Issued
2016-12-08
Date Acceptance
2016-11-29
Citation
Environment International, 2016, 99, pp.97-106
ISSN
0160-4120
Publisher
Elsevier
Start Page
97
End Page
106
Journal / Book Title
Environment International
Volume
99
Copyright Statement
© 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Identifier
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000394062700008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
Subjects
Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Environmental Sciences & Ecology
Exposome
AOP
Systems toxicology
Systems biology
Systems chemistry
Risk assessment
EFFECT-DIRECTED ANALYSIS
INTEGRATED TESTING STRATEGIES
ENVIRONMENTAL RISK-ASSESSMENT
HUMAN HAZARD CHARACTERIZATION
GENE-EXPRESSION DATA
OUTCOME PATHWAYS
PERFLUORINATED COMPOUNDS
ORGANIC MICROPOLLUTANTS
SYSTEMS TOXICOLOGY
SAFETY ASSESSMENT
Publication Status
Published