Metabolic signatures of gestational weight gain and postpartum weight loss in a lifestyle intervention study of overweight and obese women
File(s)
Published version
Author(s)
Lau, Chung Ho
Taylor-Bateman, Victoria
Vorkas, Panagiotis A
Gomes Da Graca, Goncalo
Vu, Thanh-Huyen
Type
Journal Article
Abstract
BACKGROUND: Overweight and obesity amongst women of reproductive age are increasingly common in developed economies and are shown to adversely affect birth outcomes and both childhood and adulthood health risks in the offspring. Metabolic profiling in conditions of overweight and obesity in pregnancy could potentially be applied to elucidate the molecular basis of the adverse effects of gestational weight gain (GWG) and postpartum weight loss (WL) on future risks for cardiovascular disease (CVD) and other chronic diseases. METHODS: Biofluid samples were collected from 114 ethnically diverse pregnant women with body mass index (BMI) between 25 and 40 kg/m2 from Chicago (US), as part of a randomized lifestyle intervention trial (Maternal Offspring Metabolics: Family Intervention Trial; NCT01631747). At 15 weeks, 35 weeks of gestation, and at 1 year postpartum, the blood plasma lipidome and metabolic profile of urine samples were analyzed by liquid chromatography mass spectrometry (LC-MS) and 1H nuclear magnetic resonance spectroscopy (1H NMR) respectively. RESULTS: Urinary 4-deoxyerythronic acid and 4-deoxythreonic acid were found to be positively correlated to BMI. Seventeen plasma lipids were found to be associated with GWG and 16 lipids were found to be associated with WL, which included phosphatidylinositols (PI), phosphatidylcholines (PC), lysophospholipids (lyso-), sphingomyelins (SM) and ether phosphatidylcholine (PC-O). Three phospholipids found to be positively associated with GWG all contained palmitate side-chains, and amongst the 14 lipids that were negatively associated with GWG, seven were PC-O. Six of eight lipids found to be negatively associated with WL contained an 18:2 fatty acid side-chain. CONCLUSIONS: Maternal obesity was associated with characteristic urine and plasma metabolic phenotypes, and phospholipid profile was found to be associated with both GWG and postpartum WL in metabolically healthy pregnant women with overweight/obesity. Postpartum WL may be linked to the reduction in the intake of linoleic acid/conjugated linoleic acid food sources in our study population.
Date Issued
2020-12-04
Date Acceptance
2020-12-01
Citation
Metabolites, 2020, 10 (12)
ISSN
2218-1989
Publisher
MDPI AG
Journal / Book Title
Metabolites
Volume
10
Issue
12
Copyright Statement
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
License URL
Sponsor
Imperial College Healthcare NHS Trust- BRC Funding
National Institutes of Health
Japan Society for the Promotion of Science
Identifier
https://www.mdpi.com/2218-1989/10/12/498
Grant Number
RDA27
60045948 ICSTM
20171002 & 20180913
Subjects
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
metabolic phenotyping
metabolomics
blood lipids
LC-MS
NMR
gestational weight gain
lifestyle intervention
EARLY-PREGNANCY
CHILDREN
IDENTIFICATION
ASSOCIATION
PROFILE
ACID
BMI
LC-MS
NMR
blood lipids
gestational weight gain
lifestyle intervention
metabolic phenotyping
metabolomics
0301 Analytical Chemistry
0601 Biochemistry and Cell Biology
1103 Clinical Sciences
Publication Status
Published
Date Publish Online
2020-12-04