Update on Actinobacillus pleuropneumoniae ‐ knowledge, gaps and
challenges
challenges
File(s)
Accepted version
Author(s)
Type
Journal Article
Abstract
Porcine pleuropneumonia, caused by the bacterial porcine respiratory tract pathogen Actinobacillus pleuropneumoniae, leads to high economic losses in affected swine herds in most countries of the world. Pigs affected by peracute and acute disease suffer from severe respiratory distress with high lethality. The agent was first described in 1957 and, since then, knowledge about the pathogen itself, and its interactions with the host, has increased continuously. This is, in part, due to the fact that experimental infections can be studied in the natural host. However, the fact that most commercial pigs are colonized by this pathogen has hampered the applicability of knowledge gained under experimental conditions. In addition, several factors are involved in development of disease, and these have often been studied individually. In a DISCONTOOLS initiative, members from science, industry and clinics exchanged their expertise and empirical observations and identified the major gaps in knowledge. This review sums up published results and expert opinions, within the fields of pathogenesis, epidemiology, transmission, immune response to infection, as well as the main means of prevention, detection and control. The gaps that still remain to be filled are highlighted, and present as well as future challenges in the control of this disease are addressed.
Date Issued
2018-05-01
Date Acceptance
2017-09-11
Citation
Transboundary and Emerging Diseases, 2018, 65 (Suppl. 1), pp.72-90
ISSN
0931-184X
Publisher
Wiley
Start Page
72
End Page
90
Journal / Book Title
Transboundary and Emerging Diseases
Volume
65
Issue
Suppl. 1
Copyright Statement
© 2017 Blackwell Verlag GmbH. This is the accepted version of the following article, which has been published in final form at https://onlinelibrary.wiley.com/doi/abs/10.1111/tbed.12739
Subjects
Science & Technology
Life Sciences & Biomedicine
Infectious Diseases
Veterinary Sciences
Actinobacillus pleuropneumoniae
bacterial pathogens
diagnostics
disease control
immunity
pathogenesis
transmission
RESPIRATORY SYNDROME VIRUS
ACQUIRED COLOSTRAL ANTIBODIES
BRONCHOALVEOLAR LAVAGE FLUID
HOST-DEFENSE PEPTIDE
ACUTE-PHASE RESPONSE
C-REACTIVE PROTEIN
FINISH PIG HERDS
EXPERIMENTAL-INFECTION
BIOFILM FORMATION
MYCOPLASMA-HYOPNEUMONIAE
0707 Veterinary Sciences
Publication Status
Published
Date Publish Online
2017-10-30